Meyler's Side Effects of Drugs in Cancer and Immunology by Aronson Jeffrey K

Author:Aronson, Jeffrey K.
Language: eng
Format: epub
ISBN: 9780080932880
Publisher: Elsevier Science
Published: 2012-05-27T16:00:00+00:00

Systemic sclerosis

Systemic sclerosis has been attributed to interferon alfa-2a (369).

• A 52-year-old woman received interferon alfa-2a for chronic myeloid leukemia and after about 2 years developed fever, dyspnea, and limb edema. The erythrocyte sedimentation rate was 50 mm/hour and pulmonary imaging showed pulmonary vascular congestion. She improved after interferon alfa withdrawal and administration of diuretics, but similar symptoms recurred 3 months later. She also had progressive thickening of the skin on the hands and wrists. There was diffuse parenchymal and interstitial fibrosis of the lungs, absence of peristalsis on esophagogastroduodenoscopy, renal impairment, and positive antisclero-70 antibodies. Capillaroscopy showed typical features of scleroderma. Based on these findings, a diagnosis of systemic sclerosis was suggested and she slowly improved over the next months with cyclophosphamide, prednisone, iloprost, and hydroxyurea.

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